Peptide Synthesis Reagents
T4P, 4-methylpiperidine and trityl chloride support different synthesis tasks: peptide coupling, Fmoc deprotection and protecting-group chemistry. They are not direct substitutes. Select the product against the intended reaction step, substrate, process conditions and required impurity profile.
Compare the Reagents
| Synthesis task | Product | Role | Information needed for quotation |
|---|---|---|---|
| Peptide and amide coupling | n-Butylphosphonic Anhydride (T4P) CAS 163755-62-2 |
Condensation reagent for amide, ester and peptide coupling | Required concentration, solvent, specification and quantity |
| Fmoc deprotection | 4-Methylpiperidine CAS 626-58-4 |
Base evaluated as an alternative to piperidine for Fmoc deprotection | Intended process, target grade, specification and quantity |
| Protecting-group chemistry | Trityl chloride CAS 76-83-5 |
Reagent for introducing trityl protecting groups | Substrate or functionality, target grade, specification and quantity |
Products
n-Butylphosphonic Anhydride (T4P)
CAS 163755-62-2. A condensation reagent for amide, ester and peptide coupling. Available as a 50% solution in ethyl acetate, THF, DCM or diethyl carbonate. For reaction context and work-up considerations, see the T4P coupling application overview.
4-Methylpiperidine
CAS 626-58-4. A saturated nitrogen heterocycle evaluated as a base and as an alternative to piperidine for Fmoc deprotection.
Trityl chloride
CAS 76-83-5. Triphenylmethyl chloride is used to introduce trityl protecting groups in peptide, amino-acid and nucleoside synthesis.
What to Include in an Enquiry
To review the applicable supply specification and packaging, send:
- product name and CAS number;
- intended reaction or synthesis step;
- target grade, assay and any named impurity requirements;
- required concentration and solvent, where applicable;
- quantity, preferred packaging and destination;
- required documentation, including a Certificate of Analysis or Safety Data Sheet.
Product availability, the applicable specification, packaging and batch documentation are confirmed before quotation. Suitability for a particular route should be assessed against the buyer's substrates and process conditions.